Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

Pickering emulsions (PEs) are attracting increasing attention in the areas of food, cosmetic and pharmaceutical applications owing to their surfactant-free eco-friendly nature. Herein, PEs stabilized by chitosan/collagen peptides (CH/CP) nanoparticles were assessed as green vehicles for topical delivery cannabidiol (CBD), a highly lipophilic unstable drug that is finding an appeal market. The influence oil phase volume fraction (?) type on emulsion properties, stability, rheological well ex-vivo skin absorption CBD was evaluated. PE prepared with olive (? = 0.6) exhibited elastic gel-like properties demonstrated long-term stability after 5 months storage, content 99.45% initially added amount. studies showed retained high amounts stratum corneum, while permeation extremely low, indicating produced formulations suitable vehicles. ATR-FTIR examination treated samples confirmed able overcome corneum barrier. These findings suggest CH/CP provide effective alternative CBD.